Research

Over the next few months we will be building up a research library on tick-borne diseases. This is a small selection.

Displaying 1 - 365 of 365.

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Prevention
Date Title Journal
1 Repellent efficacy of DEET, Icaridin, and EBAAP against Ixodes ricinus and Ixodes scapularis nymphs (Acari, Ixodidae) Ticks and Tick-borne Diseases
2 The management of Ixodes scapularis bites in the upper Midwest WMJ
Epidemiology
Date Title Journal
3 Incidence of Lyme disease in the UK: a population-based cohort study BMJ Open
4 Human Bartonellosis: An Underappreciated Public Health Problem? Tropical Medicine and Infectious Disease
5 Detection of tick-borne pathogens in questing Ixodes ricinus in the French Pyrenees and first identification of Rickettsia monacensis in France Parasite
6 Epidemic and research progress of babesiosis Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
7 Presence of Babesia odocoilei and Borrelia burgdorferi Sensu Stricto in a Tick and Dual Parasitism of Amblyomma inornatum and Ixodes scapularis on a Bird in Canada Healthcare (Basel, Switzerland)
8 A cross-sectional screening by next-generation sequencing reveals Rickettsia, Coxiella, Francisella, Borrelia, Babesia, Theileria and Hemolivia species in ticks from Anatolia Parasites & Vectors
9 High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden Ticks and Tick-borne Diseases
10 Far-Reaching Dispersal of Borrelia burgdorferi Sensu Lato-Infected Blacklegged Ticks by Migratory Songbirds in Canada Healthcare (Basel, Switzerland)
11 Human Babesiosis Caused by Babesia duncani Has Widespread Distribution across Canada Healthcare (Basel, Switzerland)
12 The Financial Implications of a Well-Hidden and Ignored Chronic Lyme Disease Pandemic Healthcare (Basel, Switzerland)
13 Detection of Borrelia Genomospecies 2 in Ixodes spinipalpis Ticks Collected from a Rabbit in Canada The Journal of Parasitology
14 Established Population of Blacklegged Ticks with High Infection Prevalence for the Lyme Disease Bacterium, Borrelia burgdorferi Sensu Lato, on Corkscrew Island, Kenora District, Ontario International Journal of Medical Sciences
15 Prevalence of the Lyme Disease Spirochete, Borrelia burgdorferi, in Blacklegged Ticks, Ixodes scapularis at Hamilton-Wentworth, Ontario International Journal of Medical Sciences
16 Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England Epidemiology and Infection
17 Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States Emerging Infectious Diseases
18 High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands New Microbes and New Infections
19 Next generation sequencing uncovers unexpected bacterial pathogens in ticks in western Europe PLoS One
20 A new phlebovirus associated with severe febrile illness in Missouri The New England Journal of Medicine
21 Widespread dispersal of Borrelia burgdorferi-infected ticks collected from songbirds across Canada The Journal of Parasitology
22 Prevalence of Borrelia infection in ticks from wildlife in south-west England Veterinary Record
23 Detection of Lyme disease spirochete, Borrelia burgdorferi sensu lato, including three novel genotypes in ticks (Acari: Ixodidae) collected from songbirds (Passeriformes) across Canada Journal of Vector Ecology
24 The utility of "Google Trends" for epidemiological research: Lyme disease as an example Geospatial Health
25 Assessment of polymicrobial infections in ticks in New York state Vector-Borne and Zoonotic Diseases
26 Rapid introduction of Lyme disease spirochete, Borrelia burgdorferi sensu stricto, in Ixodes scapularis (Acari: Ixodidae) established at Turkey Point Provincial Park, Ontario, Canada Journal of Vector Ecology
27 Diversity and distribution of Borrelia hermsii Emerging Infectious Diseases
28 Factors associated with the rapid emergence of zoonotic Bartonella infections Veterinary Research
29 Human babesiosis-an unrecorded reality. Absence of formal registry undermines its detection, diagnosis and treatment, suggesting need for immediate mandatory reporting Medical Hypotheses
30 Bartonella henselae in Ixodes ricinus ticks (Acari: Ixodida) removed from humans, Belluno province, Italy Emerging Infectious Diseases
31 Birds disperse ixodid (Acari: Ixodidae) and Borrelia burgdorferi-infected ticks in Canada Journal of Medical Entomology
32 Molecular evidence of Bartonella spp. in questing adult Ixodes pacificus ticks in California Journal of Clinical Microbiology
33 Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks Journal of Clinical Microbiology
34 Natural foci of tick-borne encephalitis in central Europe and the relationship of the incidence of Ixodes ricinus to original ecosystems Central European Journal of Public Health
35 Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities Arthritis and Rheumatism
Pathogenesis
Date Title Journal
36 RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From ALS, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia Frontiers in Neuroscience
37 Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies Journal of Biological Chemistry
38 A Community Study of Borrelia burgdorferi Antibodies among Individuals with Prior Lyme Disease in Endemic Areas Healthcare (Basel, Switzerland)
39 Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis PLoS One
40 Evidence of In Vivo Existence of Borrelia Biofilm in Borrelial Lymphocytomas European Journal of Microbiology & Immunology
41 Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes PLoS Neglected Tropical Diseases
42 Borrelia burgdorferi promotes the establishment of Babesia microti in the northeastern United States PLoS One
43 Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease Frontiers in Cellular and Infection Microbiology
44 Characterization of biofilm formation by Borrelia burgdorferi in vitro PLoS One
45 The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms The Open Neurology Journal
46 Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports from 2005-2012 Journal of Neuroinfectious Diseases
47 Complement split products c3a and c4a in chronic lyme disease Future Microbiology
48 Beyond cat scratch disease: widening spectrum of Bartonella henselae infection Pediatrics
49 The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders Medical Hypotheses
50 The Mystery of Morgellons disease: infection or delusion? American Journal of Clinical Dermatology
51 Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete Medical Hypotheses
52 Molecular and cellular basis of bartonella pathogenesis Annual Review of Microbiology
53 Increased arthritis severity in mice coinfected with Borrelia burgdorferi and Babesia microti The Journal of Infectious Diseases
54 Natural history of Bartonella infections (an exception to Koch's postulate) Clinical and Diagnostic Laboratory Immunology
55 Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease complex JAMA Neurology
56 Infection of fetal feline brain cells in culture with Bartonella henselae Infection and Immunity
57 Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness JAMA
58 Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years Annals of The Rheumatic Diseases
59 Antigens of Lyme disease of spirochaete Borrelia burgdorferi inhibits antigen or mitogen-induced lymphocyte proliferation FEMS Immunology and Medical Microbiology
60 Interactions of mycoplasmas with B cells: antibody production and nonspecific effects Clinical Infectious Diseases
61 MDHM, a macrophage-stimulatory product of Mycoplasma fermentans, leads to in vitro interleukin-1 (IL-1), IL-6, tumor necrosis factor, and prostaglandin production and is pyrogenic in rabbits Infection and Immunity
62 Comparative analyses of proteins extracted by hot saline or released spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis Infection and Immunity
Polymicrobial Infection
Date Title Journal
63 Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian Parasites & Vectors
64 Assessment of polymicrobial infections in ticks in New York state Vector-Borne and Zoonotic Diseases
65 Human babesiosis-an unrecorded reality. Absence of formal registry undermines its detection, diagnosis and treatment, suggesting need for immediate mandatory reporting Medical Hypotheses
66 Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease complex JAMA Neurology
67 Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness JAMA
68 Serological evidence for simultaneous occurrences of Lyme disease and babesiosis The Journal of Infectious Diseases
Transmission - Congenital
Date Title Journal
69 Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and Bartonella henselae to a child Journal of Clinical Microbiology
70 The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders Medical Hypotheses
71 Maternal Lyme disease and congenital malformations: a cord blood serosurvey in endemic and control areas Paediatric and Perinatal Epidemiology
72 Gestational Lyme borreliosis. Implications for the fetus Rheumatic Diseases Clinics of North America
73 Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy The Pediatric Infectious Disease Journal
74 Stillbirth following maternal Lyme disease New York State Journal of Medicine
75 Lyme disease during pregnancy JAMA
Transmission - General
Date Title Journal
76 Anaplasma phagocytophilum evolves in geographical and biotic niches of vertebrates and ticks Parasites & Vectors
77 Characteristics of transfusion-transmitted Babesia microti, American Red Cross 2010-2017 Transfusion
78 Lyme borreliosis: a review of data on transmission time after tick attachment International Journal of General Medicine
79 No evidence for contamination of Borrelia blood cultures: a review of facts Journal of Clinical Microbiology
80 How ticks get under your skin: insertion mechanics of the feeding apparatus of Ixodes ricinus ticks Proceedings of the Royal Society B: Biological Sciences
81 Clinical evidence for rapid transmission of Lyme disease following a tickbite Diagnostic Microbiology and Infectious Disease
82 Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease Parasites & Vectors
83 Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission Veterinary Research
84 Etiology of Oroya fever: V. The experimental transmission of Bartonella bacilliformis by ticks (Dermacentor andersoni) Journal of Experimental Medicine
Testing
Date Title Journal
85 Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model Frontiers in Cellular and Infection Microbiology
86 Single Core Genome Sequencing for Detection of both Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia Species International Journal of Environmental Research and Public Health
87 Metagenomic 16S rRNA gene sequencing survey of Borrelia species in Irish samples of Ixodes ricinus ticks PLoS One
88 Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome Journal of Central Nervous System Disease
89 Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding PLoS One
90 Update to: Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV International Journal of General Medicine
91 Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV International Journal of General Medicine
92 Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy International Journal of General Medicine
93 Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy International Journal of General Medicine
94 The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis BMC Infectious Diseases
95 Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease Journal of Clinical Microbiology
96 Quantification of Borrelia burgdorferi Membrane Proteins in Human Serum: A New Concept for Detection of Bacterial Infection Analytical Chemistry
97 Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis The Journal of Translational Medicine
98 Characteristics of seroconversion and implications for diagnosis of post-treatment Lyme disease syndrome: acute and convalescent serology among a prospective cohort of early Lyme disease patients Clinical Rheumatology
99 DNA sequencing diagnosis of off-season spirochetemia with low bacterial density in Borrelia burgdorferi and Borrelia miyamotoi infections International Journal of Molecular Sciences
100 Serum inflammatory mediators as markers of human Lyme disease activity PLoS One
101 Borrelia burgdorferi tissue morphologies and imaging methodologies European Journal of Clinical Microbiology & Infectious Diseases
102 Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease Diagnostic Microbiology and Infectious Disease
103 Direct molecular detection and genotyping of Borrelia burgdorferi from whole blood of patients with early Lyme disease PLoS One
104 Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots European Journal of Clinical Microbiology & Infectious Diseases
105 Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome PLoS One
106 Sex differences in the clinical and serologic presentation of early Lyme disease: Results from a retrospective review Gender Medicine
107 Lyme disease: a diagnostic dilemma The Nurse Practitioner
108 Chronic Lyme disease and the 'Axis of Evil' Future Microbiology
109 Lyme wars: let's tackle the testing BMJ (Clinical Research Edition)
110 Functional brain imaging and neuropsychological testing in Lyme disease Clinical Infectious Diseases
111 Cultivation and phylogenetic characterization of a newly recognized human pathogenic protozoan The Journal of Infectious Diseases
112 Detection of Babesia microti by polymerase chain reaction Journal of Clinical Microbiology
113 Seronegative Lyme disease The New England Journal of Medicine
114 Use of an autologous antigen in the serologic testing of patients with erythema migrans of Lyme disease Journal of the American Academy of Dermatology
115 Serological evidence for simultaneous occurrences of Lyme disease and babesiosis The Journal of Infectious Diseases
Diagnosis
Date Title Journal
116 Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome Journal of Central Nervous System Disease
117 Triple Tick Attack Cureus Journal of Medical Science
118 Aggressiveness, violence, homicidality, homicide, and Lyme disease Neuropsychiatric Disease and Treatment
119 Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis Veterinary Clinical Pathology
120 Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding PLoS One
121 Empirical validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for suspected Lyme disease International Journal of General Medicine
122 Suicide and Lyme and associated diseases Neuropsychiatric Disease and Treatment
123 Lyme disease: the promise of Big Data, companion diagnostics and precision medicine Infection and Drug Resistance
124 Approach to diagnosing Lyme disease misses a large proportion of cases BMJ (Clinical Research Edition)
125 Characteristics of seroconversion and implications for diagnosis of post-treatment Lyme disease syndrome: acute and convalescent serology among a prospective cohort of early Lyme disease patients Clinical Rheumatology
126 Divergent opinions of proper Lyme disease diagnosis and implications for children co-morbid with autism spectrum disorder Medical Hypotheses
127 Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection BMC Infectious Diseases
128 Bull's-Eye and Nontarget Skin Lesions of Lyme Disease: An Internet Survey of Identification of Erythema Migrans Dermatology Research and Practice
129 The Psychoimmunology of Lyme/Tick-Borne Diseases and its Association with Neuropsychiatric Symptoms The Open Neurology Journal
130 Bartonella spp. Bacteremia and rheumatic symptoms in patients from lyme disease-endemic region Emerging Infectious Diseases
131 Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports from 2005-2012 Journal of Neuroinfectious Diseases
132 The pain of chronic Lyme disease: moving the discourse backward? FASEB Journal
133 'Rare' infections mimicking multiple sclerosis: consider Lyme disease Clinical Neurology and Neurosurgery
134 Lyme disease: the next decade Infection and Drug Resistance
135 Lyme disease diagnosis and treatment: lessons from the AIDS epidemic Minerva Medica
136 Sex differences in the clinical and serologic presentation of early Lyme disease: Results from a retrospective review Gender Medicine
137 Lyme disease: a diagnostic dilemma The Nurse Practitioner
138 Morgellons disease: Analysis of a population with clinically confirmed microscopic subcutaneous fibers of unknown etiology Clinical, Cosmetic and Investigational Dermatology
139 Diagnostic challenges of early Lyme disease: lessons from a community case series BMC Infectious Diseases
140 Pediatric Lyme Disease - A School Issue: Tips for School Nurses Future Microbiology
141 Attorney General forces Infectious Diseases Society of America to redo Lyme guidelines due to flawed development process Future Microbiology
142 Unusual presentation of Lyme disease: Horner syndrome with negative serology Journal of the American Board of Family Medicine
143 Chronic Lyme disease and the 'Axis of Evil' Future Microbiology
144 STARI, or Masters disease: Lone Star tick-vectored Lyme-like illness Infectious Disease Clinics of North America
145 The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders Medical Hypotheses
146 Do Bartonella Infections Cause Agitation, Panic Disorder, and Treatment-Resistant Depression? Medscape General Medicine
147 Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete Medical Hypotheses
148 Munchausen's syndrome by proxy and Lyme disease: medical misogyny or diagnostic mystery? Medical Hypotheses
149 Evidence-based guidelines for the management of Lyme disease Expert Review of Anti-infective Therapy
150 Panic attacks may reveal previously unsuspected chronic disseminated lyme disease Journal of Psychiatric Practice
151 Functional brain imaging and neuropsychological testing in Lyme disease Clinical Infectious Diseases
152 Pitfalls in the diagnosis and treatment of Lyme disease in children JAMA
153 Late-stage neuropsychiatric Lyme borreliosis. Differential diagnosis and treatment Psychosomatics
154 Diagnosis of babesiosis: evaluation of a serologic test for the detection of Babesia microti antibody The Journal of Infectious Diseases
155 Lyme disease. Difficulties in diagnosis and management Pediatric Clinics of North America
156 Temporal arteritis associated with Borrelia infection. A case report Journal of Clinical Neuro-ophthalmology
157 Lyme disease. A neuro-ophthalmologic view Journal of Clinical Neuro-ophthalmology
158 Human babesiosis on Nantucket Island. Clinical features Annals of Internal Medicine
Persistence
Date Title Journal
159 Complement Evasion in Borrelia spirochetes: Mechanisms and Opportunities for Intervention Antibiotics
160 Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters Parasites & Vectors
161 The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype Frontiers in Microbiology
162 Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure Discovery Medicine
163 Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies Journal of Biological Chemistry
164 Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease Annals of Internal Medicine
165 Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis Veterinary Clinical Pathology
166 Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques The American Journal of Pathology
167 Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding PLoS One
168 Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding PLoS One
169 Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle Environmental Microbiology
170 Living in Limbo: Contested Narratives of Patients With Chronic Symptoms Following Lyme Disease Qualitative Health Research
171 Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts Frontiers in Immunology
172 Controversies in Persistent (Chronic) Lyme Disease Journal of Infusion Nursing
173 A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library Frontiers in Microbiology
174 Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening Drug Design, Development and Therapy
175 Isolation of live Borrelia burgdorferi sensu lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis Clinical Microbiology and Infection
176 Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime Frontiers in Microbiology
177 Biofilm formation by Borrelia burgdorferi sensu lato FEMS Microbiology Letters
178 Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells Antimicrobial Agents and Chemotherapy
179 Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library Emerging Microbes & Infections
180 Intravascular persistence of Anaplasma platys, Ehrlichia chaffeensis, and Ehrlichia ewingii DNA in the blood of a dog and two family members Parasites & Vectors
181 Resurgence of persisting non-cultivable Borrelia burgdorferi following antibiotic treatment in mice PLoS One
182 Persisters, persistent infections and the Yin-Yang model Emerging Microbes & Infections
183 Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease Frontiers in Cellular and Infection Microbiology
184 Borrelia burgdorferi tissue morphologies and imaging methodologies European Journal of Clinical Microbiology & Infectious Diseases
185 Isolation of deer tick virus (Powassan virus, lineage II) from Ixodes scapularis and detection of antibody in vertebrate hosts sampled in the Hudson Valley, New York State Parasites & Vectors
186 Review of evidence for immune evasion and persistent infection in Lyme disease International Journal of General Medicine
187 Persistent infection in chronic lyme disease: does form matter? Research Journal of Infectious Diseases
188 Type 1 and type 2 strains of Mycoplasma pneumoniae form different biofilms Microbiology (Reading, England)
189 The Aggregation of Brucella abortus Occurs Under Microaerobic Conditions and Promotes Desiccation Tolerance and Biofilm Formation The Open Microbiology Journal
190 Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here? Quality of Life Research
191 Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials Contemporary Clinical Trials
192 Characterization of biofilm formation by Borrelia burgdorferi in vitro PLoS One
193 Persistence of Non-Cultivable Borrelia burgdorferi Following Antibiotic Treatment: Critical Need for Further Research Non-journal: Testimonies
194 Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection BMC Infectious Diseases
195 Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection PLoS One
196 The lymphocyte transformation test for borrelia detects active lyme borreliosis and verifies effective antibiotic treatment The Open Neurology Journal
197 Lyme disease: the next decade Infection and Drug Resistance
198 Persister Cells Annual Review of Microbiology
199 Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin The Journal of Antimicrobial Chemotherapy
200 Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection Clinical Infectious Diseases
201 Persister Cells and the Paradox of Chronic Infections: Dormant persister cells are tolerant to antibiotics and are largely responsible for recalcitrance of chronic infections Microbe Magazine
202 Possible emergence of drug-resistant variants of Babesia gibsoni in clinical cases treated with atovaquone and azithromycin Journal of Veterinary Internal Medicine
203 Searching for autoimmunity in "antibiotic-refractory" Lyme arthritis Molecular Immunology
204 Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete Medical Hypotheses
205 In vitro susceptibility testing of Borrelia burgdorferi sensu lato isolates cultured from patients with erythema migrans before and after antimicrobial chemotherapy Antimicrobial Agents and Chemotherapy
206 Long term and repeated electron microscopy and PCR detection of Borrelia burgdorferi sensu lato after an antibiotic treatment Central European Journal of Public Health
207 Isolation and polymerase chain reaction typing of Borrelia afzelii from a skin lesion in a seronegative patient with generalized ulcerating bullous lichen sclerosus et atrophicus The British Journal of Dermatology
208 Borrelia burgdorferi detected by culture and PCR in clinical relapse of disseminated Lyme borreliosis Annals of Medicine
209 Persistent parasitemia after acute babesiosis The New England Journal of Medicine
210 Culture-positive Lyme borreliosis The Medical Journal of Australia
211 Detection of Borrelia burgdorferi by polymerase chain reaction in synovial membrane, but not in synovial fluid from patients with persisting Lyme arthritis after antibiotic therapy Annals of The Rheumatic Diseases
212 Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature Brain: A Journal of Neurology
213 Detection of Borrelia burgdorferi DNA by polymerase chain reaction in cerebrospinal fluid in Lyme neuroborreliosis The Journal of Infectious Diseases
214 Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme disease symptoms. A PCR study of 97 cases Infection
215 Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness JAMA
216 Intracellular persistence of Borrelia burgdorferi in human synovial cells Rheumatology International
217 Azithromycin and doxycycline for treatment of Borrelia culture-positive erythema migrans Infection
218 Treatment failure in erythema migrans--a review Infection
219 Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis Infection
220 Seronegative chronic relapsing neuroborreliosis European Neurology
221 The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study Annals of Internal Medicine
222 Spirochetemia After Continuous High-Dose Oral Amoxicillin Therapy Infectious Diseases in Clinical Practice
223 Chronic septic arthritis caused by Borrelia burgdorferi Clinical Orthopaedics and Related Research
224 Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis Arthritis and Rheumatism
225 First isolation of Borrelia burgdorferi from an iris biopsy Journal of Clinical Neuro-ophthalmology
226 Azithromycin versus doxycycline for treatment of erythema migrans: clinical and microbiological findings Infection
227 Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection Journal of the American Academy of Dermatology
228 Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection Journal of the American Academy of Dermatology
229 Urinary dysfunction in Lyme disease The Journal of Urology
230 Chronic neurologic manifestations of Lyme disease The New England Journal of Medicine
231 Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis Infection
232 Seronegative Lyme disease The New England Journal of Medicine
233 Spirochetes in the spleen of a patient with chronic Lyme disease The American Journal of Clinical Pathology
234 Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis The Journal of Infectious Diseases
235 Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy The Pediatric Infectious Disease Journal
236 Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue Arthritis and Rheumatism
237 Treating erythema chronicum migrans of Lyme disease Journal of the American Academy of Dermatology
238 The histopathology of experimentally infected hamsters with the Lyme disease spirochete, Borrelia burgdorferi Proceedings of the Society for Experimental Biology and Medicine
239 Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum Annals of Internal Medicine
Treatment
Date Title Journal
240 Complement Evasion in Borrelia spirochetes: Mechanisms and Opportunities for Intervention Antibiotics
241 Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases Antibiotics
242 The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype Frontiers in Microbiology
243 Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure Discovery Medicine
244 Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome Journal of Central Nervous System Disease
245 Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies Journal of Biological Chemistry
246 Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis Veterinary Clinical Pathology
247 A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library Frontiers in Microbiology
248 Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening Drug Design, Development and Therapy
249 Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime Frontiers in Microbiology
250 Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease Expert Review of Anti-infective Therapy
251 Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library Emerging Microbes & Infections
252 Pathogenicity and treatment of Bartonella infections The International Journal of Antimicrobial Agents
253 Development of a foundation for a case definition of post-treatment Lyme disease syndrome International Journal of Infectious Diseases
254 Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian Parasites & Vectors
255 Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials Contemporary Clinical Trials
256 A reappraisal of the U.S. Clinical trials of post-treatment lyme disease syndrome The Open Neurology Journal
257 Human babesiosis The New England Journal of Medicine
258 The pain of chronic Lyme disease: moving the discourse backward? FASEB Journal
259 Benefit of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease International Journal of General Medicine
260 Healthcare access and burden of care for patients with Lyme disease: a large United States survey Health Policy
261 Efficacy of prolonged antimicrobial chemotherapy for brucellar spondylodisciti Clinical Microbiology and Infection
262 The management of Ixodes scapularis bites in the upper Midwest WMJ
263 Lyme disease: the next decade Infection and Drug Resistance
264 Lyme disease diagnosis and treatment: lessons from the AIDS epidemic Minerva Medica
265 The Infectious Diseases Society of America Lyme guidelines: a cautionary tale about the development of clinical practice guidelines Philosophy, Ethics, and Humanities in Medicine (PEHM)
266 Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial Arthritis and Rheumatism
267 Safety of intravenous antibiotic therapy in patients referred for treatment of neurologic Lyme disease Minerva Medica
268 Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection Clinical Infectious Diseases
269 Attorney General forces Infectious Diseases Society of America to redo Lyme guidelines due to flawed development process Future Microbiology
270 Detrimental effects of Bartonella henselae are counteracted by L-arginine and nitric oxide in human endothelial progenitor cells Proceedings of the National Academy of Sciences of the United States of America
271 Update on lyme disease: the hidden epidemic Journal of Infusion Nursing
272 Therapeutic options for human brucellosis Expert Review of Anti-infective Therapy
273 Molecular characterization of resistance to macrolides in Bartonella henselae Antimicrobial Agents and Chemotherapy
274 Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen The International Journal of Antimicrobial Agents
275 Treatment of Lyme disease: a medicolegal assessment Expert Review of Anti-infective Therapy
276 Recommendations for treatment of human infections caused by Bartonella species Antimicrobial Agents and Chemotherapy
277 Evidence-based guidelines for the management of Lyme disease Expert Review of Anti-infective Therapy
278 Human babesiosis in New York State: Review of 139 hospitalized cases and analysis of prognostic factors JAMA Internal Medicine
279 Pitfalls in the diagnosis and treatment of Lyme disease in children JAMA
280 Treatment of late Lyme borreliosis Journal of Infection
281 Disarming Lyme disease Scientific American
282 Recurrent erythema migrans despite extended antibiotic treatment with minocycline in a patient with persisting Borrelia burgdorferi infection Journal of the American Academy of Dermatology
283 Treatment of early Lyme disease The American Journal of Medicine
284 Relapsing illness due to Rochalimaea henselae in immunocompetent hosts: implication for therapy and new epidemiological associations Clinical Infectious Diseases
285 Fatal adult respiratory distress syndrome in a patient with Lyme disease The Journal of the American Medical Association
Quality of Life
Date Title Journal
286 Living in Limbo: Contested Narratives of Patients With Chronic Symptoms Following Lyme Disease Qualitative Health Research
287 Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey PeerJ
288 Development of a foundation for a case definition of post-treatment Lyme disease syndrome International Journal of Infectious Diseases
289 Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here? Quality of Life Research
290 Healthcare access and burden of care for patients with Lyme disease: a large United States survey Health Policy
Case Studies
Date Title Journal
291 Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases Antibiotics
292 Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome Journal of Central Nervous System Disease
293 Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis Veterinary Clinical Pathology
294 First record of locally acquired human babesiosis in Canada caused by Babesia duncani: a case report SAGE Open Medical Case Reports
295 Case report: Molecular evidence of Anaplasma platys infection in two women from Venezuela The American Journal of Tropical Medicine and Hygiene
296 Bartonella henselae bacteremia in a mother and son potentially associated with tick exposure Parasites & Vectors
297 Neurological Manifestations of Bartonellosis in Immunocompetent Patients: A Composite of Reports from 2005-2012 Journal of Neuroinfectious Diseases
298 Beyond cat scratch disease: a case report of bartonella infection mimicking vasculitic disorder Case Reports in Infectious Diseases
299 Co-isolation of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from blood, joint and subcutaneous seroma fluids from two naturally infected dogs Veterinary Microbiology
300 Diagnostic challenges of early Lyme disease: lessons from a community case series BMC Infectious Diseases
301 Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease complex JAMA Neurology
302 Severe babesiosis in Long Island: review of 34 cases and their complications Clinical Infectious Diseases
303 Brucellar spondylitis: review of 35 cases and literature survey Clinical Infectious Diseases
304 Human babesiosis in New York State: Review of 139 hospitalized cases and analysis of prognostic factors JAMA Internal Medicine
305 Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature Brain: A Journal of Neurology
306 Spirochetemia After Continuous High-Dose Oral Amoxicillin Therapy Infectious Diseases in Clinical Practice
307 Current perspective on Lyme borreliosis JAMA
308 Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy The Pediatric Infectious Disease Journal
Reviews
Date Title Journal
309 Complement Evasion in Borrelia spirochetes: Mechanisms and Opportunities for Intervention Antibiotics
310 Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters Parasites & Vectors
311 Lyme borreliosis: a review of data on transmission time after tick attachment International Journal of General Medicine
312 Antibiotic retreatment of Lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials Contemporary Clinical Trials
313 Persistence of Non-Cultivable Borrelia burgdorferi Following Antibiotic Treatment: Critical Need for Further Research Non-journal: Testimonies
314 Treatment failure in erythema migrans--a review Infection
Other
Date Title Journal
315 Health care costs, utilization and patterns of care following Lyme disease PLoS One
316 Lyme disease and post-treatment Lyme disease syndrome: the neglected disease in our own backyard Public Health
317 Patient-powered research networks aim to improve patient care and health research Health Affairs
318 Morgellons disease, illuminating an undefined illness: a case series Journal of Medical Case Reports
319 Munchausen's syndrome by proxy and Lyme disease: medical misogyny or diagnostic mystery? Medical Hypotheses
320 How the discovery of Borrelia burgdorferi came about Clinics in Dermatology
Unknown
Date Title Journal
321 Borrelia Diversity and Co-infection with Other Tick Borne Pathogens in Ticks Frontiers in Cellular and Infection Microbiology
322 Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques Journal of Alzheimer's Disease
323 The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability Molecular Neurobiology
324 A study on the association between infectious burden and Alzheimer's disease European Journal of Neurology
325 Historic evidence to support a causal relationship between spirochetal infections and Alzheimer's disease Frontiers in Aging Neuroscience
326 Broad-range survey of tick-borne pathogens in Southern Germany reveals a high prevalence of Babesia microti and a diversity of other tick-borne pathogens Vector-Borne and Zoonotic Diseases
327 Chronic or late lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis The Open Neurology Journal
328 Emerging roles of pathogens in Alzheimer disease Expert Reviews in Molecular Medicine
329 Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria Journal of Neuroinflammation
330 First detection of spotted fever group rickettsiae in Ixodes ricinus and Dermacentor reticulatus ticks in the UK Epidemiology and Infection
331 A clear and present danger: tick-borne diseases in Europe Expert Review of Anti-infective Therapy
332 Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis Journal of Neuroinflammation
333 Chronic inflammation and amyloidogenesis in Alzheimer's disease -- role of Spirochetes Journal of Alzheimer's Disease
334 Empirical validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for suspected Lyme disease International Journal of General Medicine
335 Alzheimer's disease Braak Stage progressions: reexamined and redefined as Borrelia infection transmission through neural circuits Medical Hypotheses
336 Alzheimer's neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes Medical Hypotheses
337 Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid Clinical Infectious Diseases
338 Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes Neurobiology of Aging
339 Transfection "Junk" DNA - a link to the pathogenesis of Alzheimer's disease? Medical Hypotheses
340 Spirochetal cyst forms in neurodegenerative disorders,...hiding in plain sight Medical Hypotheses
341 Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease Journal of Alzheimer's Disease
342 The clinical spectrum of early Lyme borreliosis in patients with culture-confirmed erythema migrans The American Journal of Medicine
343 Lyme disease. NIH gears up to test a hotly disputed theory Science (New York, N.Y.)
344 Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease NeuroReport
345 Lyme disease: an infectious and postinfectious syndrome The Journal of Rheumatology
346 Physician beliefs, attitudes, and approaches toward Lyme disease in an endemic area Clinical Pediatrics
347 Alzheimer's disease--a spirochetosis? NeuroReport
348 Identification of nonsteroidal antiinflammatory drug-induced gastroduodenal injury in children with juvenile rheumatoid arthritis The Journal of Pediatrics
349 Early Lyme disease: a flu-like illness without erythema migrans Pediatrics
350 Lyme disease associated with fibromyalgia Annals of Internal Medicine
351 The neuropsychiatric manifestations of Lyme borreliosis Psychiatric Quarterly
352 Lyme borreliosis: ten years after discovery of the etiologic agent, Borrelia burgdorferi Infection
353 The Jarisch-Herxheimer reaction in leptospirosis: possible pathogenesis and review Reviews of Infectious Diseases
354 Clinical implications of delayed growth of the Lyme borreliosis spirochete, Borrelia burgdorferi Acta Tropica
355 Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease JAMA Neurology
356 Immunodiagnosis of Lyme borreliosis Rheumatic Diseases Clinics of North America
357 Late stage Lyme borreliosis in children Southern Medical Journal
358 Lyme disease. The hidden pandemic The Postgraduate Medical Journal
359 Fatal adult respiratory distress syndrome in a patient with Lyme disease JAMA
360 Concurrent neocortical borreliosis and Alzheimer's disease Human Pathology
361 Facial paralysis in Lyme disease The Laryngoscope
362 The spirochetal etiology of lymphocytic meningoradiculitis of Bannwarth (Bannwarth's syndrome) Journal of Neurology
363 Lyme disease-a tick-borne spirochetosis? Science (New York, N.Y.)
364 Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities Arthritis and Rheumatism
365 Clinical pathology of the Jarisch-Herxheimer reaction The Journal of Infectious Diseases