Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease

Published Date
Journal
NeuroReport
Citation
Neuroreport. 1994 Jun 2;5(10):1201-4
DOI
10.1097/00001756-199406020-00010
Authors
Miklossy J
Kasas S
Janzer RC
Ardizzoni F
Van der Loos H
Abstract

Recently it was reported that, at autopsy, in neuropathologically confirmed cases of Alzheimer's disease spirochaetes were found in blood and cerebrospinal fluid using dark-field microscopy. Moreover, the spirochaetes were isolated and cultured from brain tissue. We now show, using scanning electron microscopy and atomic force microscopy that the helically shaped microorganisms isolated and cultured from the Alzheimer brains possess axial filaments. This indicates that these microorganisms taxonomically indeed belong to the order Spirochaetales. A morphometric analysis reinforces this notion.