Clinical pathology of the Jarisch-Herxheimer reaction

Published Date
Journal
The Journal of Infectious Diseases
Citation
J Infect Dis. 1976 Jun;133(6):696-704
DOI
10.1093/infdis/133.6.696
Authors
Bryceson AD
Abstract

The Jarisch-Herxheimer reaction is a complication that can follow treatment of several infectious diseases. Its most severe form is in louse-borne relapsing fever; in this syndrome the reaction can cause death. Information from studies in Ethiopia during the past eight years is presented, and clinical, physiological, pathological, and immunological features of the reaction are described. Possible causative mechanisms of the reaction are discussed, especially in relation to the role of endotoxin, and an attempt is made to consider this reaction in relation to other endotoxin-associated states.