Lyme disease, 1988: immunologic manifestations and possible immunopathogenetic mechanisms

Published Date
Seminars in Arthritis and Rheumatism
Semin Arthritis Rheum. 1989 Feb;18(3):151-67
Sigal LH

In 1975, STEERE ET AL reported a cluster of cases of inflammatory arthropathy from persons living in three small Connecticut towns.’
Some of the patients recalled a distinctive skin rash, erythema chronicum migrans (ECM), preceding the arthritis. Since this initial report, Lyme arthritis has been recognized as part of the multisystem entity now known as Lyme disease (LD). Detailed descriptions of the clinical’ and pathological3 manifestations of LD have been presented in recent reviews and in the proceedings of the three international symposia on LD.4-6. The purpose of this review is to summarize the studies of the causative agent, Borrelia burgdorferi, and of the cellular and humoral immune changes seen in LD. This information will be used to formulate proposed immunopathogenetic mechanisms explaining the clinical manifestations and tissue damage found in LD in the United States and in Europe.