Antibody testing in Lyme disease. A comparison of results in four laboratories

Published Date
Journal
JAMA
Citation
JAMA. 1989 Dec 22-29;262(24):3431-4
DOI
10.1001/10.1001/jama.1989.03430240067031
Authors
Schwartz BS
Goldstein MD
Ribeiro JM
Schulze TL
Shahied SI
Abstract

To evaluate the interlaboratory and intralaboratory agreement in the performance of Lyme disease serological testing, we sent serum specimens from 132 outdoor workers in New Jersey to as many as four independent laboratories. These included one state department of health laboratory, one large commercial laboratory, and two research laboratories. The measurement of agreement employed, the kappa statistic, ranged from .45 to .53 among the four laboratories and from .50 to .54 within the commercial laboratory. These values represent low levels of agreement. The data suggest that Lyme disease serological testing procedures should be standardized so that Lyme disease test results are more comparable between laboratories.