Immune escape strategies of Borrelia burgdorferi

Published Date
Journal
Future Microbiology
Citation
Future Microbiol. 2017 Oct;12:1219-1237
DOI
10.2217/fmb-2017-0013
Authors
Aslam B
Nisar MA
Khurshid M
Farooq Salamat MK
Abstract

The borrelial resurge demonstrates that Borrelia burgdorferi is a persistent health problem. This spirochete is responsible for a global public health concern called Lyme disease. B. burgdorferi faces diverse environmental conditions of its vector and host during its life cycle. To circumvent the host immune system is a prominent feature of B. burgdorferi. To date, numerous studies have reported on the various mechanisms used by this pathogen to evade the host defense mechanisms. This current review attempts to consolidate this information to describe the immunological and molecular methods used by B. burgdorferi for its survival.