Chronic neurologic manifestations of Lyme disease

Published Date
Journal
The New England Journal of Medicine
Citation
N Engl J Med. 1991 Apr 18;324(16):1137
DOI
10.1056/NEJM199104183241615
Authors
Stark E
Wurster U
Abstract

Lyme disease, caused by the tick-borne spirochete Borrelia burgdorferi, is associated with a wide variety of neurologic manifestations. To define further the chronic neurologic abnormalities of Lyme disease, we studied 27 patients (age range, 25 to 72 years) with previous signs of Lyme disease, current evidence of immunity to B. burgdorferi, and chronic neurologic symptoms with no other identifiable cause. Eight of the patients had been followed prospectively for 8 to 12 years after the onset of infection.