Seronegative chronic relapsing neuroborreliosis

Published Date
Journal
European Neurology
Citation
Eur Neurol. 1995;35(2):113-7
DOI
10.1159/000117104
Authors
Lawrence C
Lipton RB
Lowy FD
Coyle PK
Abstract

We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.